Protective Effects of the Green Tea Polyphenol(-)-epigallocatechin Gallate Against Ischemia Reperfusion Injury Induced by Middle Cerebral Artery Occlusion in Rats
Journal of the Korean Neurological Association
;
: 387-391, 2003.
Article
in Korean
| WPRIM
| ID: wpr-95816
ABSTRACT
BACKGROUND:
EGCG(epigallocatechin gallate), a major green tea extract, is a potent free radical scavenger which has been shown to reduce free radical-induced lipid peroxidation. The purpose of this study was to examine whether EGCG reduces focal ischemia/reperfusion-induced brain injury in rats.METHODS:
Male Wistar rats were anesthetized with ketamine and xylazine and subjected to 120 min of temporary middle cerebral artery occlusion by an intraluminal nylon suture coated with poly-L-lysine. The drug (EGCG, n=8) or vehicle (normal saline, n=8) was administered iv.(as a 50 mg/kg bolus) immediately after the onset of middle cerebral artery occlusion. Neurologic status was evaluated 2 hours after occlusion and 24 hours after. Twenty-four hours after ischemia, the brain was perfusion-fixated and the infarct volume was determined.RESULTS:
EGCG significantly improved the neurological status at 24 hours after middle cerebral artery occlusion.(p<0.05), and reduced total infarct volumes (p<0.01).CONCLUSIONS:
These results demonstrate the neuroprotective effect of EGCG in a rat model of transient focal cerebral ischemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sutures
/
Tea
/
Xylazine
/
Brain
/
Brain Injuries
/
Lipid Peroxidation
/
Reperfusion Injury
/
Brain Ischemia
/
Rats, Wistar
/
Neuroprotective Agents
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2003
Type:
Article
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