Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer
Korean Journal of Urology
;
: 435-442, 2015.
Article
in English
| WPRIM
| ID: wpr-95910
ABSTRACT
PURPOSE:
Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma. MATERIALS ANDMETHODS:
A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsy sampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-microm sections were treated with CD34 antibodies and were digitized by using an image analysis system that automatically estimates the surface fractal dimension.RESULTS:
Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlations were found between the vascular surface fractal dimension and patient's age, PSA and free-to-total PSA ratios, pathological stage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence.CONCLUSIONS:
The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancer tissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmark of intermediate- and high-risk prostate cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatectomy
/
Prostatic Neoplasms
/
Biopsy, Needle
/
Image Processing, Computer-Assisted
/
Kallikreins
/
Retrospective Studies
/
Prostate-Specific Antigen
/
Fractals
/
Neoplasm Grading
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Urology
Year:
2015
Type:
Article
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