The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1100-1106, 2007.
Article
in Korean
| WPRIM
| ID: wpr-95974
ABSTRACT
OBJECTIVE:
To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.METHODS:
Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining.RESULTS:
Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413).CONCLUSION:
PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Retrospective Studies
/
Mitosis
Type of study:
Observational study
/
Prognostic study
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2007
Type:
Article
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