Reference values for nerve conduction studies in healthy newborns, infants and children in Philippine Children's Medical Center

ABSTRACT

@#<p style="text-align justify;"><strong>BACKGROUND:</strong> Nerve conduction studies play a diagnostic role in the clinical evaluation of neuromuscular disorders in children. Reference ranges define the expected parameter values in disease-free children.</p><p style="text-align justify;"><strong>OBJECTIVE:</strong> To propose reference values for sensory and motor nerve conduction and late responses in upper and lower limb peripheral nerves in Filipino children 5 years and below.</p><p style="text-align justify;"><strong>METHODS</strong> Sensory nerve conduction studies on median, ulnar, superficial peroneal, and sural nerves and motor nerve conduction and late response studies on median, ulnar, peroneal and posterior tribal nerves were done using standardized techniques among 100 healthy Filipino children.</p><p style="text-align justify;"><strong>RESULTS:</strong> Subjects were stratified according to age groups. Reference values for the following parameters (1) sensory conduction velocity and amplitude; (2) motor conduction velocity, amplitude and latency at distal sites;  (3) F-wave latency; and (4) H-reflex latency were summarized. These were expressed as mean ±standard deviation or median (range) for values that follow Gaussian and non-Gaussian distributions. The 5th and 95th percentile values were likewise reported. Age had direct correlation with various nerve conduction parameters. Height was directly correlated with F-wave parameters of median, ulnar and peroneal nerves but not posterior tribal nerve.</p><p style="text-align justify;"><strong>CONCLUSIONS</strong> Reference standards for nerve conduction studies of commonly tested nerves of Filipino children are presented. Values are comparable to reference ranges elsewhere except for the H-reflex latency which is higher in this study.</p>