Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis
Intestinal Research
;
: 250-258, 2015.
Article
in English
| WPRIM
| ID: wpr-96058
ABSTRACT
BACKGROUND/AIMS:
The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with thiopurine in UC patients.METHODS:
This was a retrospective observational cohort analysis conducted at a single center. Between December 1998 and August 2013, 59 of 87 patients with bio-naive UC who achieved remission after induction with treatments other than biologics were enrolled. Remission maintenance with thiopurine was defined as no concomitant treatment needed other than 5-aminosalicylate without relapse. We assessed the remission-maintenance rate, mucosal healing rate, colectomy-free rate, and treatment safety in UC patients who received thiopurine as maintenance treatment.RESULTS:
The 84-month cumulative remission-maintenance and colectomy-free survival rates in the UC patients who were receiving maintenance treatment with thiopurine and 5-aminosalicylate were 43.9% and 88.0%, respectively. Of the 38 patients who underwent colonoscopy during thiopurine maintenance treatment, 23 (60.5%) achieved mucosal healing. Of the 59 patients who achieved clinical remission with thiopurine, 6 patients (10.2%) discontinued the thiopurine therapy because of adverse events.CONCLUSIONS:
Our study demonstrates the long-term efficacy and safety of thiopurine treatment in patients with bio-naive UC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Biological Products
/
Colitis, Ulcerative
/
Survival Rate
/
Retrospective Studies
/
Cohort Studies
/
Colonoscopy
/
Mesalamine
/
Asian People
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Intestinal Research
Year:
2015
Type:
Article
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