Effectiveness and adverse effects of Intravenous Colistin In Neonates with Multi-Drug Resistant Gram-Negative Bacterial Infections
Pediatric Infectious Disease Society of the Philippines Journal
;
: 16-25, 2020.
Article
in English
| WPRIM
| ID: wpr-962197
ABSTRACT
Background@#The global burden of multi-drug resistant gram-negative bacterial (MDR-GNB) infections has been increasing. Neonates are at a particularly high-risk and there is limited treatment option. The use of colistin has been re-introduced for this population. However, data on its use in neonates is scarce. @*Objectives@#To determine the effectiveness and adverse effects of intravenous colistin in neonates with multidrug-resistant gram-negative infections. @*Design@#This is a retrospective cohort study of the clinical profile and outcome of neonates with MDR-GNB infections given colistin for a minimum of 3 days conducted from April 2015 to April 2019. @*Results@#A total of 175 pediatric patients had MDR-GNB infections. 75 (43%) neonates met the inclusion criteri a and received intravenous colistin. Of the 75 patients with MDRGNB infections- that included sepsis, pneumonia, urinary tract infection and abscess, 37 (49.3%) were alive and 38 (50.7%) patients died. Nephrotoxicity was seen in 4% if patients and 2.6% patients had hypersensitivity reaction. MDROs isolated were Acinetobacter baumanii, Klebsiella pneumoniae and Pseudomonas aeruginosa. @*Conclusions@#Intravenous colistin is 50% effective and is relatively safe to use in neonates.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colistin
Limits:
Infant, Newborn
Language:
English
Journal:
Pediatric Infectious Disease Society of the Philippines Journal
Year:
2020
Type:
Article
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