Effect of the G-CSF schedule for harvesting peripheral blood progenitor cells from healthy donors / 대한내과학회지
Korean Journal of Medicine
;
: 553-558, 2008.
Article
in Korean
| WPRIM
| ID: wpr-9624
ABSTRACT
BACKGROUND/AIMS:
Peripheral blood progenitor cells (PBSC) have been used instead of bone marrow cells for allogeneic transplantation. Progenitor cells are mobilized using granulocyte colony stimulating factor (G-CSF). Kinetic studies of G-CSF have shown that the CD34+ cells peak on day 5, although the optimal time for harvesting has not been established.METHODS:
We compared two mobilization schedules using G-CSF. In groups I and II, G-CSF 10 microgram/kg/day was administered subcutaneously for 3 or 4 days, respectively, and leukapheresis was performed the next day.RESULTS:
In groups I and II, a respective mean number of 5.84 x 106 and 10.76 x 106 circulating CD34+ cells per kilogram of the recipient's weight was collected by leukapheresis. The yield of the two collections did not differ significantly (p=0.386).CONCLUSION:
This study suggested that the two mobilization schedules are equally effective. To avoid prolonged exposure to G-CSF, the day 4 collection schedule is the preferred mobilization strategy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appointments and Schedules
/
Stem Cells
/
Tissue Donors
/
Transplantation, Homologous
/
Bone Marrow Cells
/
Granulocyte Colony-Stimulating Factor
/
Colony-Stimulating Factors
/
Leukapheresis
/
Granulocytes
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2008
Type:
Article
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