Quantitative comparison of atropine and tricyclamol with standard blocking agents of neuromascular transmission in cats under dial-urethane anesthesia

ABSTRACT

A quantitative comparison of atropine sulfate and tricyclamol chloride with tubocurarine chloride with tubocurarine chloride and succinylcholine chloride on neuromuscular block reveals the following salient observations 1. Atropine and tricyclamol produce neuromuscular blockade comparable with that caused by tubocurarine and succinylcholine2. With regard to potency by dose, tubocurarine is 55 times more potent than tricyclamol and 277 times more potent than atropine; while succinylcholine is 250 times more potent than tricyclamol and 1250 times more potent than atropine3. Atropine causes the longest duration of neuromuscular block, outlasting that which is produced by tubocurarine4. Tricyclamol gives a transient blockade which closely resembles the one elicited by succinylcholine. (Summary)