Reactive Oxygen Species (ROS) in Cancer and Cancer Stem Cells Spesies Oksigen Reaktif (ROS) dalam Kanser dan Kanser Stem Sel (CSC) / Jurnal Sains Kesihatan Malaysia
Malaysian Journal of Health Sciences
;
: 35-41, 2021.
Article
in English
| WPRIM
| ID: wpr-964548
ABSTRACT
@#Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress and cytotoxic. Oxidative stress can lead to cancer. But on the other hand, the radiotherapy treatment method induces the formation of ROS in the process of cell death. Resistance therapy in cancer cells is associated with high antioxidant enzymes that neutralize ROS in cancer cells. In addition, therapeutic resistance and recurrence are also associated with the presence of cancer stem cells (CSCs). Several studies have shown that ROS levels are found to be low in CSCs. Low levels of ROS are likely to play a role in the survival of CSCs. Therefore, modulation of ROS levels in CSCs can be used as an alternative therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Malaysian Journal of Health Sciences
Year:
2021
Type:
Article
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