Morroniside Inhibits Hydrogen Peroxide-induced Apoptosis in SH-SY5Y Neuroblastoma Cells / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 428-430, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-964756
ABSTRACT
@#Objective To investigate the effects of morroniside on hydrogen peroxide (H2O2)-induced apoptosis in SH-SY5Y neuroblastoma cells. Methods SH-SY5Y cells were pre-incubated with morroniside (1, 10, and 100 μmol/L) for 24 h prior to exposure to H2O2 (300~500 μmol/L) for 18 h. The content of malondialdehyde (MDA),mitochondrial membrane potentials (MMP) and apoptosis ratio were determined. Results Pretreatment the cells with morroniside (1, 10 and 100 μmol/L) lowered the H2O2-induced MDA concentration and MMP, and inhibited the apoptosis. Conclusion Morroniside may protect the neurocyte from H2O2-induced apoptosis by lowered MDA and inhibits MMP.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2009
Type:
Article
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