Effect of Ferroptosis on Organ Fibrosis and Intervention Progress of Traditional Chinese Medicine： A Review / 中国实验方剂学杂志

ABSTRACT

Fibrosis refers to the disorder of repair response after tissue damage， which is mainly characterized by the increase of fibrous connective tissue and the decrease of parenchymal cells in organs. Progressive fibrosis can lead to the destruction of tissue structure and organ failure. Ferroptosis is a new type of programmed cell death， which is caused by the accumulation of iron dependent lipid peroxides and regulated by iron metabolism， iron autophagy， amino acid metabolism and lipid metabolism. Ferroptosis plays an important role in the pathological process of fibrosis， participating in many pathological processes such as organ parenchymal cell injury， macrophage inflammation， oxidative stress and myofibroblast transformation. Studies have shown that ferroptosis occurs in myofibroblasts during extracellular matrix deposition in the fibrous cascade reaction， and the targeted regulation of ferroptosis can effectively reduce chronic organ injury and tissue fibrosis. It has been confirmed that a variety of traditional Chinese medicine and its active components can regulate the ferroptosis parenchyma cells of organs and play an anti-fibrosis effect， showing a good research prospect. This article summarizes the role of ferroptosis in the pathological process of liver， lung， kidney and heart fibrosis and the intervention of related Chinese medicine， in order to provide a new target for Chinese medicine to prevent and treat fibrosis.