Flow Cytometric Analysis of Lymphocyte Subpopulations of Cattle Infected with Bovine Leukemia Virus
Journal of Bacteriology and Virology
;
: 165-173, 2005.
Article
in Korean
| WPRIM
| ID: wpr-9650
ABSTRACT
We examined lymphocyte subpopulations of peripheral blood from BLV infected and noninfected Holstein-Friesian dairy cattle reared in Korea by flow cytometry using monoclonal antibodies specifically reactive with bovine leukocyte differentiation marker. Lymphocyte subpopulations expressing BoCD11b, B-B2, CD5, B, MHC II-DP, MHC II-DQ, and MHC II-DR antigens were significantly abundant in the BLV(+) group than the BLV(-) group (p<0.01). On double staining, subpopulation of B-1a(BoCD5+ BoCD11b+) lymphocytes was significantly increased in leukemic group. However, T-lymphocyte lineage expressing BoCD2, BoCD4, BoCD8, and WC1 antigens was significantly lower than in the BLV(+) group (p<0.01). However the absolute number of T-lymphocytes expressing BoCD2, BoCD4, BoCD8, and WC1 antigens in BLV(+) group remained with in the normal range. Furthermore mean ratio of BoCD4/BoCD8 in the BLV(+) groups was higher than that in the BLV(-) group. Taken together, cellular immune responses did not seem to significantly be decreased in the leukemic cattle.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Lymphocytes
/
T-Lymphocytes
/
Lymphocyte Subsets
/
Enzootic Bovine Leukosis
/
Leukemia Virus, Bovine
/
Flow Cytometry
/
Immunity, Cellular
/
Korea
/
Leukocytes
Limits:
Animals
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2005
Type:
Article
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