Electrophysiological and Morphological Changes After Intravitreal Bevacizumab Injection with Macular Edema or Choroidal Neovascularization
Journal of the Korean Ophthalmological Society
;
: 1824-1830, 2009.
Article
in Korean
| WPRIM
| ID: wpr-96511
ABSTRACT
PURPOSE:
To evaluate the functional and anatomical statuses of macula with multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) for the treatment of patients with macular edema after intravitreal bevacizumab injection.METHODS:
Patients were injected with intravitreal bevacizumab (1.875 mg/0.075 ml) for macular edema with choroidal neovascularization (CNV), diabetic retinopathy and retinal vein occlusion.RESULTS:
A total of 120 eyes (96 patients) were diagnosed with diabetic retinopathy, CNV with age-related macular degeneration and retinal vein occlusion. Visual acuity improved from logMAR 0.85+/-0.39 to 0.54+/-0.38 after intravitreal bevacizumab injection. The implicit time of P1 and N2 in mfERG decreased, and the amplitude of P1 showed a statistically significant increase. Central macular thickness decreased from 374.4+/-135.2 micrometer to 249.0+/-72.0 micrometer.CONCLUSIONS:
After intravitreal bevacizumab injection, functional and anatomical statuses of mfERG and OCT improved. This study demonstrates a method for utilizing mfERG to assess the effectiveness of treatments such as bevacizumab.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinal Vein Occlusion
/
Visual Acuity
/
Macular Edema
/
Choroid
/
Choroidal Neovascularization
/
Tomography, Optical Coherence
/
Diabetic Retinopathy
/
Eye
/
Antibodies, Monoclonal, Humanized
/
Bevacizumab
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2009
Type:
Article
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