Expression of p27kip1 and Cyclin D1 in Serous Epithelial Ovarian Tumors
Korean Journal of Pathology
; : 220-225, 2001.
Article
in Ko
| WPRIM
| ID: wpr-96592
Responsible library:
WPRO
ABSTRACT
BACKGROUND: p27kip1 is a member of the Cip/Kip family of the cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Decreased expression of p27kip1 is associated with high histologic grade and poor prognosis in a variety of human tumors. METHODS: Sixty-six cases of serous epithelial ovarian tumors were investigated by immunohistochemical staining for p27kip1, cyclin D1, and Ki-67. Clinicopathologic parameters (WHO classification, histologic grade and FIGO stage) were compared with the incidence of p27kip1, cyclin D1 and Ki-67 protein expression in ovarian serous tumors. RESULTS: Reduced expression of p27kip1 was found more freguently in serous cystadenocarcinoma than in serous cystadenoma and borderline malignancy (p<0.05). The decreased expression of p27kip1 was correlated with a high histologic grade and an advanced FIGO stage. Overexpression of cyclin D1 is associated with borderline malignancy and grade I serous cystadenocarcinoma. An inverse relationship was observed between the p27kip1 protein and the Ki-67 labeling index within serous cystadenocarcinoma, but it was not significant. CONCLUSIONS: Reduced expression of p27kip1 protein plays an important role in the biologically aggressive behavior of serous epithelial ovarian tumors and might represent a useful prognostic marker for predicting the recurrence in primary ovarian tumors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Ovarian Neoplasms
/
Phosphotransferases
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Prognosis
/
Recurrence
/
Incidence
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Genes, Tumor Suppressor
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Classification
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Cyclins
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Cystadenoma, Serous
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Cystadenocarcinoma, Serous
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Pathology
Year:
2001
Type:
Article