Electron microscopic study of the cases of minimal change nephrotic syndrome with mesangial IgA deposition
Yonsei Medical Journal
;
: 351-356, 1992.
Article
in English
| WPRIM
| ID: wpr-96628
ABSTRACT
Twenty-five cases of minimal change nephrotic syndrome(minimal change disease, MCD) with mesangial IgA deposition were evaluated electron microscopically. The thickness of the glomerular basement membrane(GBM) was 3875 +/- 1271 A and 3056 +/- 1201 A in adults and children, respectively. Alteration of the GBM was noted in 3 adults and eight children splitting in 4, focal thinning in one, widening of the lamina rara interna in 10, and widening of the lamina rara externa in 4 cases. Minimal mesangial electron dense deposits were found in all but one adult, and an increase of the mesangial matrix and minimal mesangial proliferation were observed in 8 and 6 cases, respectively. Electron microscopic findings show representative findings of MCD in our cases. A relationship between the GBM alterations in these cases and frequent association of hematuria is suggested and discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin A
/
Glomerular Mesangium
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
1992
Type:
Article
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