Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis
Yonsei Medical Journal
;
: 309-319, 1992.
Article
in English
| WPRIM
| ID: wpr-96633
ABSTRACT
Immunohistochemical study on 26 cases of Langerhans cell histiocytosis (LCH) using several leukocyte antibodies in addition to traditionally used markers (S-100 protein and peanut agglutinin) revealed that the proliferating cells of LCH expressed UCHL1, MT1 as well as classically known positivity for S-100 protein, HLA-DR and peanut agglutinin but were negative for OPD4. In comparison to S-100 protein peanut agglutinin (PNA) using a two stage method produced weaker staining and positively stained cells were sparse. Also in this study, a small proportion of proliferating cells in LCH was observed to be reactive for both myeloid/macrophage antigens (KPI, MAC 387 and lysozyme) and Langerhans cell marker (S-100 protein), verifying the existence of a hybrid form of histiocytes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Staining and Labeling
/
Immunohistochemistry
/
Histiocytosis, Langerhans-Cell
/
Middle Aged
/
Antigens
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1992
Type:
Article
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