Analysis of the Effects of Macrophage Colony Stimulating Factor with Image Analysis in Tattoo Removal Using Alexandrite Laser Surgery / 대한피부과학회지
Korean Journal of Dermatology
;
: 746-751, 1999.
Article
in Korean
| WPRIM
| ID: wpr-96666
ABSTRACT
BACKGROUND:
Tattoos are acquired pigmented lesions of the skin, and the Q-switched alexandrite laser has been shown to be effective in removing blue-black as well as green, red and mauve colored tattoos. Following the laser therapy, macrophage phagocytes the altered pigment. Macrophage-colony stimulating factor(M-CSF) may influence the macrophage activities.OBJECTIVE:
This study was conducted to evaluate the potential adjunctive effect of M-CSF in tattoo removal with laser treatment.METHOD:
A prospective study was taken, in 8 guinea pigs and 8 mice, to evaluate the clinical and histopathological clearing of tattoo pigment following the laser treatment of the tattoo at the M-CSF injection site.RESULTS:
1) Clinically, the tattoo resolved more rapidly with Alexandrite laser therapy in the M-CSF treated group. 2) Histopathologically, by using image analysis, there was no significant difference in the relative ratio of dermal tattoo pigment and tattoo containing cells, between laser treated(1.54% in guinea pig, 1.09% in mouse) and laser with M-CSF treated group(1.44% in guinea pig, 0.95% in mouse).CONCLUSION:
Our study reveals the role of M-CSF as an adjuvant in tattoo removal using Alexandrite laser surgery. However, further prospective animal studies and human trials, are needed to evaluate the action mechanism of M-CSF at the intradermal injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytes
/
Skin
/
Injections, Intradermal
/
Prospective Studies
/
Macrophage Colony-Stimulating Factor
/
Colony-Stimulating Factors
/
Laser Therapy
/
Lasers, Solid-State
/
Guinea Pigs
/
Macrophages
Type of study:
Observational study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1999
Type:
Article
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