Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders / 소아과
Korean Journal of Pediatrics
;
: 420-424, 2014.
Article
in English
| WPRIM
| ID: wpr-96674
ABSTRACT
The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The first clinical presentations were chronic respiratory symptoms and recurrent pneumonia. The symptoms worsened in the following 2 years. The results of in situ hybridization were positive for EBV, which led to a diagnosis of LIP. The diagnosis was confirmed by the results of a thoracoscopic lung biopsy. The EBV titer of the bronchoalveolar lavage specimens obtained after acyclovir treatment was found to be fluctuating. The patient had latent EBV infection for 8 years, until presented at the hospital with intermittent abdominal pain and distension. Physical examination and pelvic computed tomography revealed a large mesenteric mass. A biopsy of the excised mass led to a diagnosis of Burkitt's lymphoma (BL). The patient received combination chemotherapy for 4 months, consisting of vincristine, methotrexate, cyclophosphamide, doxorubicin, and prednisolone. He is now tumor-free, with the LIP under control, and is being followed-up at the outpatient clinic. This is the first report of a Korean case of chronic latent EBV infection that developed into LIP and BL in a nonimmunocompromised child.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Physical Examination
/
Pneumonia
/
Vincristine
/
Biopsy
/
Acyclovir
/
Prednisolone
/
B-Lymphocytes
/
Doxorubicin
/
Abdominal Pain
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2014
Type:
Article
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