Experimental reproduction of proliferative enteropathy and the role of IFN-gamma in protective immunity against Lawsonia intracellularis in mice
Journal of Veterinary Science
;
: 357-359, 2005.
Article
in English
| WPRIM
| ID: wpr-96780
ABSTRACT
Proliferative enteropathy was reproduced in IFN-gamma receptor knockout (IFN-gamma R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-gamma were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-gamma produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Viral
/
Polymerase Chain Reaction
/
Interferon-gamma
/
Receptors, Interferon
/
Mice, Knockout
/
Lawsonia Bacteria
/
Desulfovibrionaceae Infections
/
Intestinal Diseases
/
Intestinal Mucosa
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2005
Type:
Article
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