T-Cell Dysfunction and Inhibitory Receptors in Hepatitis C Virus Infection
Immune Network
;
: 120-125, 2010.
Article
in English
| WPRIM
| ID: wpr-96924
ABSTRACT
Dysfunction of the virus-specific T cells is a cardinal feature in chronic persistent viral infections such as one caused by hepatitis C virus (HCV). In chronic HCV infection, virus-specific dysfunctional CD8 T cells often overexpress various inhibitory receptors. Programmed cell death 1 (PD-1) was the first among these inhibitory receptors that were identified to be overexpressed in functionally impaired T cells. The roles of other inhibitory receptors such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) have also been demonstrated in T-cell dysfunctions that occur in chronic HCV patients. Blocking these inhibitory receptors in vitro restores the functions of HCV-specific CD8 T cells and allows enhanced proliferation, cytolytic activity and cytokine production. Therefore, the blockade of the inhibitory receptors is considered as a novel strategy for the treatment of chronic HCV infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulins
/
T-Lymphocytes
/
Cell Death
/
Hepatitis C
/
Hepacivirus
/
Hepatitis
/
Mucins
Limits:
Humans
Language:
English
Journal:
Immune Network
Year:
2010
Type:
Article
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