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Research progress on the relationship between periodontal pathogens and colorectal cancer / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases ; (12): 513-517, 2023.
Article in Chinese | WPRIM | ID: wpr-969306
ABSTRACT
@#With the deepening of the research on the relationship between oral microbiota and systemic diseases, researchers have found that periodontitis is closely related to diabetes, cardiovascular disease, digestive system disease and other systemic diseases. Fusobacterium nucleatum (Fn) and Porphyromonas gingivalis (Pg) are common periodontal pathogens, which play a key role in the occurrence and development of periodontitis. At present, it is also found that Fn and Pg are closely related to the occurrence and development of colorectal cancer (CRC). They can affect the occurrence and development of CRC and the therapeutic effect and prognosis of CRC patients through a variety of ways. It can promote tumor cell proliferation by regulating cell division cycle and inhibiting cell apoptosis, inhibit immune cell function to mediate immune escape and tumor metastasis, and create a pro-inflammatory microenvironment suitable for tumor survival. The study of the effect of periodontal pathogens on the occurrence and development of colorectal cancer and its mechanism also allows us to think about new methods, such as vaccine development, immune agents and antibiotic use to better prevent and treat colorectal cancer and improve the prognosis of patients with colorectal cancer.

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Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Prevention and Treatment for Stomatological Diseases Year: 2023 Type: Article

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Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Prevention and Treatment for Stomatological Diseases Year: 2023 Type: Article