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Progress in research of risk prediction of non-syndromic oral clefts using genetic information / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 504-510, 2023.
Article in Zh | WPRIM | ID: wpr-969935
Responsible library: WPRO
ABSTRACT
Non-syndromic oral cleft (NSOC), a common birth defect, remains to be a critical public health problem in China. In the context of adjustment of childbearing policy for two times in China and the increase of pregnancy at older childbearing age, NSOC risk prediction will provide evidence for high-risk population identification and prenatal counseling. Genome-wide association study and second generation sequencing have identified multiple loci associated with NSOC, facilitating the development of genetic risk prediction of NSOC. Despite the marked progress, risk prediction models of NSOC still faces multiple challenges. This paper summarizes the recent progress in research of NSOC risk prediction models based on the results of extensive literature retrieval to provide some insights for the model development regarding research design, variable selection, model-build strategy and evaluation methods.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Risk Factors / Cleft Lip / Cleft Palate / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Genome-Wide Association Study Limits: Humans Language: Zh Journal: Chinese Journal of Epidemiology Year: 2023 Type: Article
Full text: 1 Index: WPRIM Main subject: Risk Factors / Cleft Lip / Cleft Palate / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Genome-Wide Association Study Limits: Humans Language: Zh Journal: Chinese Journal of Epidemiology Year: 2023 Type: Article