New mechanisms of chronic kidney disease-associated vascular calcification / 生理学报
Acta Physiologica Sinica
;
(6): 913-926, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-970087
ABSTRACT
Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Cardiovascular Diseases
/
Proteins
/
Disease Progression
/
Myocytes, Smooth Muscle
/
Renal Insufficiency, Chronic
/
Vascular Calcification
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2022
Type:
Article
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