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Update on the role and mechanism of erythropoietin receptor in acute kidney injury and repair or fibrosis / 生理学报
Acta Physiologica Sinica ; (6): 115-129, 2023.
Article in Chinese | WPRIM | ID: wpr-970112
ABSTRACT
Acute kidney injury (AKI) is a common critical disease clinically with high morbility and mortality and some survival patients also progress to chronic kidney disease. Renal ischemia-reperfusion (IR) is one of the main causes of AKI, in which, its repair and potential fibrosis, apoptosis, inflammation and phagocytosis play important roles. During the progression of IR-induced AKI, the expression of erythropoietin homodimer receptor (EPOR)2 and EPOR and β common receptor formed heterodimer receptor (EPOR/βcR) is changed dynamically. Moreover, (EPOR)2 and EPOR/βcR may synergistically participate in renoprotection at the stage of AKI and early repair, whereas at the late stage of AKI, the (EPOR)2 induces renal fibrosis and the EPOR/βcR facilitates repair and remodelling. The underlying mechanism, signaling pathways and the different effect turning point of (EPOR)2 and EPOR/βcR have not been well defined. It has been reported that EPO, according to its 3D structure, derived helix B surface peptide (HBSP) and cyclic HBSP (CHBP) only bind to EPOR/βcR. Synthesized HBSP, therefore, provides an effective tool to distinguish the different roles and mechanisms of both receptors, with the (EPOR)2 promoting fibrosis or the EPOR/βcR leading to repair/remodelling at the late stage of AKI. This review discusses the similarities and differences of (EPOR)2 and EPOR/βcR in their impacts on apoptosis, inflammation and phagocytosis in AKI, repair and fibrosis post IR, associated mechanisms, signaling pathways and outcomes.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Reperfusion Injury / Receptors, Erythropoietin / Apoptosis / Acute Kidney Injury / Inflammation Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Reperfusion Injury / Receptors, Erythropoietin / Apoptosis / Acute Kidney Injury / Inflammation Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2023 Type: Article