Application of self-assembly in polypeptide drugs: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 177-191, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-970367
ABSTRACT
Self-assembly refers to the spontaneous process where basic units such as molecules and nanostructured materials form a stable and compact structure. Peptides can self-assemble by non-covalent driving forces to form various morphologies such as nanofibers, nano layered structures, and micelles. Peptide self-assembly technology has become a hot research topic in recent years due to the advantages of definite amino acid sequences, easy synthesis and design of peptides. It has been shown that the self-assembly design of certain peptide drugs or the use of self-assembled peptide materials as carriers for drug delivery can solve the problems such as short half-life, poor water solubility and poor penetration due to physiological barrier. This review summarizes the formation mechanism of self-assembled peptides, self-assembly morphology, influencing factors, self-assembly design methods and major applications in biomedical field, providing a reference for the efficient use of peptides.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Pharmaceutical Preparations
/
Amino Acid Sequence
/
Drug Delivery Systems
/
Nanostructures
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2023
Type:
Article
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