Extracellular Signal-regulated Kinase 1/2 Signaling Regulates Cell Invasion:a Review / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 155-160, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-970461
ABSTRACT
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase (MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Cell Cycle
/
Mitogen-Activated Protein Kinases
/
Mitogen-Activated Protein Kinase 3
/
Cell Proliferation
Limits:
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Type:
Article
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