The Effect of Mitomycin C Concentration in Endonasal Dacryocystorhinostomy

ABSTRACT

PURPOSE: We applied mitomycin C in different concentrations and times into osteotomy site during surgery to observe its effects and compare the success rates between two groups. METHODS: Fifty-three patients (53 eyes) who presented with chronic epiphora symptoms underwent endonasal dacryocystorhinostomy (DCR) and silicon tube intubation in our hospital between november, 2002 and january, 2004. In group A, mitomycin C at 0.25 mg/ml was applied into the osteotomy site for 3minutes during the operation, in group B mitomycin at 0.5 mg/ml was applied for 5 minutes. Success was defined as the absence of any epiphora symptoms and good passage by punctum irrigation test. RESULTS: The primary success rate of endonasal DCR was 83% (44/53). 78.1% (25/32) in group A, and 90.4% (19/21) in group B. Three failed patients were reoperated and applied at the same concentration and the same duration as previously. The total success rate was 88.7% (47/53) ; 84.4% (27/32) in group A, 95.2% (20/21) in group B. However the difference of success rates between the two groups was not significant statistically (P=0.384, Fisher's exact test). CONCLUSIONS: The success rate of mitomycin C at 0.25 mg/ml for 3 minutes application was not significantly different from that of mitomycin C at 0.5 mg/ml for 5 minutes.