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Research advances in the role of MAPK cascade in regulation of cell growth, immunity, inflammation, and cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 1721-1728, 2022.
Article in English | WPRIM | ID: wpr-971356
ABSTRACT
Mitogen-activated protein kinase (MAPK) cascade system is one of the highly conserved signal systems in eukaryotic cells, which participates in the regulation of many biological processes. Under the stimulation of different signals (such as cytokines, neurotransmitters, and hormones), MAPK cascade activates downstream targets and controls a variety of cellular processes, including growth, immunity, inflammation, and stress response. In different cells, the effects of MAPK cascade on cells vary with the stimuli and the duration of stimulation. MAPK cascade induces Th differentiation and participates in T cell receptor signal pathway and B cell receptor signal pathway. MAPK cascades regulate various cellular activities related to the occurrence and development of cancer. A thorough and systematic understanding of the specific regulatory effects of MAPK cascade on various cellular processes will provide theoretical guidance for treating various diseases.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Cell Cycle / MAP Kinase Signaling System / Inflammation / Neoplasms Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Cell Cycle / MAP Kinase Signaling System / Inflammation / Neoplasms Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2022 Type: Article