Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 425-439, 2023.
Article
in English
| WPRIM
| ID: wpr-971574
ABSTRACT
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, including chronic pain. Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exaggerate pain signals under chronic pain conditions. It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Therefore, this review presents our current understanding of the roles of astrocytes in chronic pain, how they regulate nociceptive responses, and their cellular and molecular mechanisms of action.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Neuroglia
/
Astrocytes
/
Chronic Disease
/
Synaptic Transmission
/
Chronic Pain
/
Neurons
Limits:
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2023
Type:
Article
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