Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 491-502, 2023.
Article
in English
| WPRIM
| ID: wpr-971583
ABSTRACT
As prominent immune cells in the central nervous system, microglia constantly monitor the environment and provide neuronal protection, which are important functions for maintaining brain homeostasis. In the diseased brain, microglia are crucial mediators of neuroinflammation that regulates a broad spectrum of cellular responses. In this review, we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration. We further provide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases. Notably, we propose microglial depletion and subsequent repopulation as promising replacement therapy. Although microglial replacement therapy is still in its infancy, it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Central Nervous System
/
Microglia
/
Neurodegenerative Diseases
/
Homeostasis
Limits:
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2023
Type:
Article
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