RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 11-11, 2023.
Article
in English
| WPRIM
| ID: wpr-971598
ABSTRACT
Tumor-associated macrophages (TAMs) play crucial roles in tumor progression and immune responses. However, mechanisms of driving TAMs to antitumor function remain unknown. Here, transcriptome profiling analysis of human oral cancer tissues indicated that regulator of G protein signaling 12 (RGS12) regulates pathologic processes and immune-related pathways. Mice with RGS12 knockout in macrophages displayed decreased M1 TAMs in oral cancer tissues, and extensive proliferation and invasion of oral cancer cells. RGS12 increased the M1 macrophages with features of increased ciliated cell number and cilia length. Mechanistically, RGS12 associates with and activates MYC binding protein 2 (MYCBP2) to degrade the cilia protein kinesin family member 2A (KIF2A) in TAMs. Our results demonstrate that RGS12 is an essential oral cancer biomarker and regulator for immunosuppressive TAMs activation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Repressor Proteins
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Kinesins
/
GTP-Binding Proteins
/
RGS Proteins
/
Ubiquitin-Protein Ligases
/
Adaptor Proteins, Signal Transducing
/
Squamous Cell Carcinoma of Head and Neck
/
Tumor-Associated Macrophages
Limits:
Animals
/
Humans
Language:
English
Journal:
International Journal of Oral Science
Year:
2023
Type:
Article
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