The Influences of Vascular Endothlelial Growth Factor and Endothelin-1 on Speramtogenesis in Testis / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 235-244, 2004.
Article
in Korean
| WPRIM
| ID: wpr-97231
ABSTRACT
OBJECTIVE:
The effects on spermatogenesis by expression of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were investigated. MATERIALS ANDMETHODS:
Testicular specimens were obtained from 40 infertile males due to primary testicular failure and from 10 fertile males with other urologic problems. The specimens of infertile males were devided into 4 groups according to histologic findings; Sertoli cell only syndrome (A), maturation arrest (B), hypospermatogenesis (C) and sloughing and disorganization (D). VEGF and ET-1 expression were detected with immunohistochemical stain.RESULTS:
VEGF expression on Leydig cell was detected in all cases. But, VEGF expression rates on germ cell were significantly higher in infertile group B, C, D compared to that of the control group (p0.05). In germ cell of infertile group, LH, FSH and prolactin were significantly decreased, and estradiol is increased in positive stain group on ET-1 immunohistochemical stain (p0.05).CONCLUSIONS:
Abnormal spermatogenesis would be reflected in VEGF expression in germ cell.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Prolactin
/
Seminiferous Tubules
/
Spermatogenesis
/
Testis
/
Endothelin-1
/
Vascular Endothelial Growth Factor A
/
Estradiol
/
Sertoli Cell-Only Syndrome
/
Germ Cells
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Fertility and Sterility
Year:
2004
Type:
Article
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