Statistical Analysis of Prognostic Factors on Renal Pelvis Tumors / 대한비뇨기과학회지

ABSTRACT

We performed a retrospective analysis of 25 patients presenting with confirmed renal pelvis tumor to examine factors predictive of survival outcome. Follow-up duration was from 11 to 133 months (mean 39 months). The analysis of prognostic factors was performed on 26 cases with available clinical data, testing the following parameters age, symptom duration, IVP finding, urine cytology, concomitant tumor, histopathological grade, stage, treatment modality and also correlation between each factors was examined. The analysis showed that grade (p <0.001) and stage (p =0.001) were the only two parameters having a statistically significant impact on prognosis, multifocality also had some influence on survival(p<0.05 ). In cases of low-stage, low-grade tumor (stage I-II according to Bennington and Bechkwith classification and grade I - II according to Broder's classification) the probability of survival was 90%. 86% at 5 years, but in high-stage, high-grade tumor, 5 year survival rates were 28 % and 0% respectively. In 20 of total 25 cases nephroureterectomy with bladder cuff excision was performed, simple nephrectomy in 2 cases, radical or palliative nephrectomy in 3 cases, but no survival difference was observed in treatment modality. This finding suggests that early diagnosis and surgical excision of the pelvis tumor will result in excellent outcome but the survival of patients with high stage and high grade tumor probably can not be improved without the development of effective adjuvant therapy.