Results of study of some pharmacology for “Usu-3” traditional drug / Монголын эм зүй, эм судлал

ABSTRACT

Abstract@#Diabetes is describe as a disease of the thirst (undaasah) in the four foundations of traditional drug (Kh. Tumbaa, 1991).</br> There are drugs such as Jur Ur-4, Sopagi-14, Yunva-4 and Usu-3 used for thirst disease. One of the main medicines used in Mongolian traditional drug is “Usu-3”. This is drug with 3 ingredients (Coriandrum sativum L.), (Inula helenium L.), (Hippophae rhamnoides L.). Each of these ingredients were studied indivudually, but not studied in combination.@*Purpose@#To study liver protection effects and toxicity of the “Usu-3” traditional drug in the pathological diabetic model.@*Methods@#The experiment were performed using acute and chronic toxicity study by Organization economic cooperation development (OECD 423), effect of antihyperglycemic and antihyperlipidemic on the alloxan induced diabetic milletus. (Sheriff Modu*, A. Laila et al, 2011) and (Ju JB, Kim JS et al, 2008) method.@*Results@#</br> 1. The “Usu-3” traditional drug was tested in animals at a dose of 5 to 5000 mg/kg in accordance with OECD guideline 423 for acute toxicity study and was found to be harmless in the GHS category. Therefore showed no signs of chronic poisoning with the maximum dose determined for chronic toxicity studies oral administration by 5000mg/kg for 2 months.</br> 2. The “Usu-3” traditional drug’s group has been shown to reducing the levels of Aspartate Aminotransferase and Alanine Aminotransferease comparison with other groups. @*Conclusion@#“Usu-3” traditional drug was found to be harmless in the GHS category, showed no signs of acute and chronic toxicity. </br> “Usu-3” traditional drug have a protection effect for liver at short and medium time in alloxan induced diabetic rats model.