Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer
Radiation Oncology Journal
;
: 99-107, 2012.
Article
in English
| WPRIM
| ID: wpr-97539
ABSTRACT
PURPOSE:
The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. MATERIALS ANDMETHODS:
The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a boost of 5.4 Gy in 3 fractions to the primary tumor with 5 fractions per week. Three different chemotherapy regimens were used (5-fluorouracil and leucovorin, capecitabine, or tegafur/uracil). Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and pathologic complete response (ypCR). Statistical analyses were performed to identify clinical factors associated with pathologic tumor response.RESULTS:
Tumor downstaging was observed in 28 patients (54.9%), whereas ypCR was observed in 6 patients (11.8%). Multivariate analysis found that predictors of downstaging was pretreatment relative lymphocyte count (p = 0.023) and that none of clinical factors was significantly associated with ypCR.CONCLUSION:
Pretreatment relative lymphocyte count (%) has a significant impact on the pathologic tumor response (tumor downstaging) after preoperative CRT for locally advanced rectal cancer. Enhancement of lymphocyte-mediated immune reactions may improve the effect of preoperative CRT for rectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pelvis
/
Rectal Neoplasms
/
Leucovorin
/
Multivariate Analysis
/
Lymphocyte Count
/
Deoxycytidine
/
Chemoradiotherapy
/
Capecitabine
/
Fluorouracil
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2012
Type:
Article
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