Results of toxicity for medical nanomaterialsin vitro / Монголын Анагаах Ухаан
Mongolian Medical Sciences
;
: 9-12, 2015.
Article
in English
| WPRIM
| ID: wpr-975460
ABSTRACT
BACKGROUND:
Nano is a key technology to bring accelerated development in science, economy and business in 21stcentury. Besides lots of advantages contained in nanoproducts, cytotoxic effects on human and environmentmay occur due to their extreme small size and large surface area and it promotes chemical reaction andactivates reactive oxygen species in the cell. In the last few decades, human and environment exposureof nanomaterials have been increasing, but research papers related to nanomaterial toxicity have beenpoor.GOAL Determination of nanomaterial toxicity in medical applicationMATERIALS ANDMETHODS:
Totally 21 nanomaterials collected in this study including imported nano-medicines, disinfectantspray, cleaning solution and experimental nanomaterial produced in Mongolia. The particle sizesof nanomaterialswere determined by Cross correlation analysis and X-Ray diffraction analysis, andmutagenicity was determined by Ames test.RESULTS:
The particle sizes of nanomaterials in 5 of 21 were measured at the range of 1 – 100nm and 5 of 21nanomaterials were determined as mutagenic by Ames test.CONCLUSION:
Ingredients and production methods can be one of causes of nanomaterial toxicity. Therefore, morespecific methods are needed to reveal cytotoxicity of nanomaterials in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Mongolian Medical Sciences
Year:
2015
Type:
Article
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