Plasma level of Apolipoprotein A for coronary artery disease / Монголын Анагаах Ухаан

ABSTRACT

IntroductionCoronary artery disease is a leading cause of death among men and women globally. Researchershave focused on apolipoproteins for coronary artery disease (CAD) than traditional lipid parameterssuch as total cholesterol, LDL-C and HDL-C. Measuring Apolipoprotein B (Apo-B) provides a directestimate of the total number of atherogenic particles. Also lipoprotein (a) [LP (a)] is super atherogeniclipoprotein that resembles the LDL containing apo-B in its structure and associated with development ofatherosclerosis and thrombogenesis.GoalTo determine some specifi c lipid markers such as apo-B, LP (a) and traditional lipid parameters forcoronary atherosclerosis and compare with healthy groupMaterials and MethodsHospital based case control study. The study included 42 patients undergoing coronary angiographywith >75% narrowing of main coronary arteries and 43 healthy controls. We collected data of traditionallipid parameters by “endpoint” method and apo-B, LP (a) by “immunoturbidometry method” from ROCHECOBAS 6000 analyzer series.ResultÀpo-Â and Lp(a) were 108.88±26.61 mg/dl, 19.50±24.86 mg/dl and signifi cantly higher in patientswith coronary artery disease (CAD) versus control group. Total cholesterol, especially LDL-C thatApo-B is major on its surface signifi cantly different in the study groups (p<0.05). Also, other lipoproteinthat containing apo-B, one of them is LP (a) were higher in the case group (p≤0.05) compared withhealthy controls. Logistic regression analysis showed that Apo-B were one of main risk factors for CAD(OR=1.024, p=0.013).ConclusionOur fi ndings suggest that LDL-C