Analysis of Oropharyngeal Microbiota between the Patients with Bronchial Asthma and the Non-Asthmatic Persons
Journal of Bacteriology and Virology
;
: 270-278, 2013.
Article
in English
| WPRIM
| ID: wpr-97575
ABSTRACT
Bronchial asthma can be triggered by microbial agents in the oropharynx. This study was designed to identify the differences in microbiota of oropharynx of bronchial asthmatic patients in contrast to normal controls. In order to resolve the qualitative and quantitative diversity of the 16S rRNA gene present in the oropharynx microbiota of 4 patients and 4 controls, we compared microbial communities using Sanger sequencing and 376 sequences of 16S rRNA gene were analyzed. Of the total microbial diversity detected in the oropharynx in asthmatic patients 45.6% comprised members of the Firmicutes. In contrast, Proteobacteria (44.0%) dominated the oropharyngeal microbiota in the normal control group. Members of the Bacteroidetes, Fusobacteria, Actinobacteria, TM7, Cyanobacteria and unclassified bacteria were present in both groups. In conclusion, the difference in the microbiota of the oropharynx between patients and normal individuals could trigger symptomatic attacks in bronchial asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oropharynx
/
Asthma
/
Bacteria
/
Actinobacteria
/
Cyanobacteria
/
Genes, rRNA
/
Proteobacteria
/
Bacteroidetes
/
Fusobacteria
/
Metagenome
Type of study:
Qualitative research
Limits:
Humans
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2013
Type:
Article
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