A case of two consecutive deliveries in a woman with acromegaly / 대한내과학회지
Korean Journal of Medicine
;
: 662-666, 2004.
Article
in Korean
| WPRIM
| ID: wpr-97663
ABSTRACT
Acromegaly is a rare pituitary disorder and usually results from GH hypersecretion by a somatotroph adenoma. Disturbed pituitary function might lead to infertility or early pregnancy termination. Pregnancy in acromegaly is very rare. GH is a potent insulin antagonist, and pregnant patients with GH hypersecretion are prone to added glucose intolerance and diabetes. Pregnancy itself may impact the course of a pituitary tumor. In our case, pregnancy was uneventful and normal full-term infant was delivered at 1993 by vaginal delivery after transsphenoidal surgery and bromocriptine therapy. After delivery, GH and IGF-I level wasn't normalized. Postoperative pituitary MRI scan showed residual tumor. Therefore she received subsequent postoperative pituitary radiation (total dose 5000 cGy). Next year, despite elevated GH and IGF-I, she delivered normal full-term infant. We report a case of two consecutive deliveries in a woman with acromegaly despite elevated GH and IGF-I levels after transsphenoidal surgery and radiation therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Diseases
/
Pituitary Neoplasms
/
Acromegaly
/
Insulin-Like Growth Factor I
/
Growth Hormone
/
Magnetic Resonance Imaging
/
Bromocriptine
/
Glucose Intolerance
/
Neoplasm, Residual
/
Growth Hormone-Secreting Pituitary Adenoma
Limits:
Female
/
Humans
/
Infant
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2004
Type:
Article
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