Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 166-175, 2023.
Article
in English
| WPRIM
| ID: wpr-977413
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the microbiome becomes perturbed, causing dysbiosis. Increased representation of members in the Proteobacteria phylum and certain members in the Firmicutes phylum has been associated with increased risk of exacerbations and mortality. Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2023
Type:
Article
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