Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population / 中国药房
China Pharmacy
;
(12): 1661-1664, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-977861
ABSTRACT
Meropenem is the first choice for the treatment of multi-drug-resistant bacterial infections, which has been widely used in clinical practice. However, the physiological and pathological characteristics of special populations have a significant impact on the pharmacokinetics/pharmacodynamics (PK/PD) parameters of meropenem, so it is necessary to develop individualized drug administration plan according to the characteristics of patients in clinical application. Therefore, this paper summarizes PK/PD characteristics and application of meropenem in special population, and recommends the dosage of meropenem as follows: 10-40 mg/kg, q8 h for children; 1 g, q8-12 h for elderly patients; 0.75 g, q8 h for the patients with renal insufficiency who received continuous veno-venous hemofiltration and continuous veno-venous hemodialysis; 1 g, q8 h prolonged infusion until 3 hours or 2 g, q8 h for patients with hyperrenal function; 1 g, q8 h after 2 g loading dose for patients with cirrhosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2023
Type:
Article
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