The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 384-390, 2014.
Article
in English
| WPRIM
| ID: wpr-9786
ABSTRACT
BACKGROUND:
Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative NV, including intraoperative NV, and changes in serum 5-HT concentrations. We evaluated the relationship between perioperative NV and serum 5-HT levels in patients undergoing cesarean section under epidural anesthesia, and carried out a pilot study to determine if further studies on a larger scale were justified.METHODS:
Twenty-eight patients who were scheduled for cesarean section under epidural anesthesia were included in the study. Patients were assigned to 2 groups according to the occurrence of NV after induction, i.e., an NV-positive or an NV-negative group. Serum 5-HT concentrations were measured before induction, at the time that NV occurred (in the case of the NV-positive group) or 5 min after the umbilical cord clamping (in the case of the NV-negative group) during surgery, and at 2 h postoperatively.RESULTS:
NV occurred in 10 of the 28 patients. No significant differences in serum 5-HT concentrations were found within or between the two groups.CONCLUSIONS:
This study suggests that there is no correlation between serum 5-HT concentration and the occurrence of perioperative NV in patients undergoing cesarean section under epidural anesthesia, and the findings do not seem to support further investigations regarding a possible relationship between serum 5-HT concentration and perioperative NV.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Umbilical Cord
/
Vomiting
/
Serotonin
/
Cesarean Section
/
Pilot Projects
/
Constriction
/
Receptors, Serotonin, 5-HT3
/
Anesthesia, Epidural
/
Nausea
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2014
Type:
Article
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