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Two new ursane triterpenoids from Agastache rugosa (Fisch. et.Mey.) O. Kuntze / 药学学报
Yao Xue Xue Bao ; (12): 1650-1654, 2023.
Article in Zh | WPRIM | ID: wpr-978736
Responsible library: WPRO
ABSTRACT
Two new ursane triterpenoids along with twelve known compounds were isolated from 80% ethanol extract of Agastache rugosa (Fisch. et. Mey.) O. Kuntze by using silica gel column, MCI column, ODS column and HPLC. The structures of the new compounds were identified as 2α,3α-dihydroxy-24-nor-urs-4(23),12(13)-dien-28-oic acid (1) and 2α,3α-dihydroxy-24-nor-urs-4(23),12(13),20(30) -trien-28-oic acid (2) by HR-ESI-MS, NMR and ECD spectral data, named agasursacid A and agasursacid B. In addition, compounds 3, 4, 6, 8 showed anti-coxsackievirus B3 (CVB3) activities with a IC50 as 4.77, 1.59, 11.11 and 25.87 μmol·L-1, resepectively.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Yao Xue Xue Bao Year: 2023 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Yao Xue Xue Bao Year: 2023 Type: Article