The triggering receptor expressed on myeloid cells 2-apolipoprotein E signaling pathway in diseases / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1291-1299, 2023.
Article
in English
| WPRIM
| ID: wpr-980925
ABSTRACT
Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane receptor on myeloid cells and plays an important role in the body's immune defense. Recently, TREM2 has received extensive attention from researchers, and its activity has been found in Alzheimer's disease, neuroinflammation, and traumatic brain injury. The appearance of TREM2 is usually accompanied by changes in apolipoprotein E (ApoE), and there has been a lot of research into their structure, as well as the interaction mode and signal pathways involved in them. As two molecules with broad and important roles in the human body, understanding their correlation may provide therapeutic targets for certain diseases. In this article, we reviewed several diseases in which TREM2 and ApoE are synergistically involved in the development. We further discussed the positive or negative effects of the TREM2-ApoE pathway on nervous system immunity and inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Signal Transduction
/
Microglia
/
Myeloid Cells
/
Alzheimer Disease
/
Neuroinflammatory Diseases
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2023
Type:
Article
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