Microbial production of S-adenosyl-l-methionine: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2248-2264, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-981201
ABSTRACT
S-adenosyl-l-methionine (SAM) is ubiquitous in living organisms and plays important roles in transmethylation, transsulfuration and transamination in organisms. Due to its important physiological functions, production of SAM has attracted increasing attentions. Currently, researches on SAM production mainly focus on microbial fermentation, which is more cost-effective than that of the chemical synthesis and the enzyme catalysis, thus easier to achieve commercial production. With the rapid growth in SAM demand, interests in improving SAM production by developing SAM hyper-producing microorganisms aroused. The main strategies for improving SAM productivity of microorganisms include conventional breeding and metabolic engineering. This review summarizes the recent research progress in improving microbial SAM productivity to facilitate further improving SAM productivity. The bottlenecks in SAM biosynthesis and the solutions were also addressed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
S-Adenosylmethionine
/
Fermentation
/
Metabolic Engineering
/
Plant Breeding
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS