Advances on the microbial synthesis of plant-derived diterpenoids / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2265-2283, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-981202
ABSTRACT
Natural plant-derived diterpenoids are a class of compounds with diverse structures and functions. These compounds are widely used in pharmaceuticals, cosmetics and food additives industries because of their pharmacological properties such as anticancer, anti-inflammatory and antibacterial activities. In recent years, with the gradual discovery of functional genes in the biosynthetic pathway of plant-derived diterpenoids and the development of synthetic biotechnology, great efforts have been made to construct a variety of diterpenoid microbial cell factories through metabolic engineering and synthetic biology, resulting in gram-level production of many compounds. This article summarizes the construction of plant-derived diterpenoid microbial cell factories through synthetic biotechnology, followed by introducing the metabolic engineering strategies applied to improve plant-derived diterpenoids production, with the aim to provide a reference for the construction of high-yield plant-derived diterpenoid microbial cell factories and the industrial production of diterpenoids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants
/
Biotechnology
/
Diterpenes
/
Biosynthetic Pathways
/
Synthetic Biology
/
Metabolic Engineering
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2023
Type:
Article
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