Advances in Modeling of Multiple Myeloma in Mice / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 512-518, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-981299
ABSTRACT
Multiple myeloma(MM)is a systemic malignancy of plasma cells.Nowadays,the basic research on MM is flourishing with the continuous optimization and innovation of mouse models of MM.Heterologous mouse models of MM established with human-derived cells and immunodeficient mice have been applied in assessing drug efficacy,exploring drug resistance mechanisms,and observing tumor-bone marrow microenvironment interactions.In the last decades,the homologous mouse models of MM established with murine-derived cells or gene-editing technologies have been widely used in the research on the pathogenesis and drug development.Additionally,the stable modeling of targeted organ injury will be a key problem to be tackled in this field.This review summarizes the characteristics and application progress of mouse models of MM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Drug Resistance
/
Disease Models, Animal
/
Tumor Microenvironment
/
Multiple Myeloma
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Type:
Article
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