Application and development of systems biology in computer-aided drug design / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2868-2875, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-981421
ABSTRACT
With the advances in medicine, people have deeply understood the complex pathogenesis of diseases. Revealing the mechanism of action and therapeutic effect of drugs from an overall perspective has become the top priority of drug design. However, the traditional drug design methods cannot meet the current needs. In recent years, with the rapid development of systems biology, a variety of new technologies including metabolomics, genomics, and proteomics have been used in drug research and development. As a bridge between traditional pharmaceutical theory and modern science, computer-aided drug design(CADD) can shorten the drug development cycle and improve the success rate of drug design. The application of systems biology and CADD provides a methodological basis and direction for revealing the mechanism and action of drugs from an overall perspective. This paper introduces the research and application of systems biology in CADD from different perspectives and proposes the development direction, providing reference for promoting the application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Design
/
Genomics
/
Systems Biology
/
Drug Development
/
Medicine
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2023
Type:
Article
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