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Chemical constituents from Callicarpa kwangtungensis and their hemostatic activities / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3815-3825, 2023.
Article in Chinese | WPRIM | ID: wpr-981514
ABSTRACT
This study aims to identify the chemical constituents from Callicarpa kwangtungensis and determine their activities. MCI, ODS, and Sephadex LH-20 chromatography and semi-preparative HPLC were employed to separate the chemical constituents. A total of 15 compounds were separated, and their structures were identified on the basis of spectroscopic analysis and comparison with the data in relevant literature. Specifically, the 15 compounds were 3-O-α-L-rhamnopyranosyl-6-O-β-D-apiofuranosyl-4-O-E-caffeoyl-D-glucopyranoside(1), 3,6-O-α-L-dirhamnopyranosyl-4-O-E-caffeoyl-D-glucopyranoside(2), β-OH-forsythoside B(3), β-OH-poliumoside(4),(+)-lyoniresinol-3α-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside(5),(+)-lyoniresinol-3α-O-β-D-glucopyranoside(6),(-)-lyoniresinol-3α-O-β-D-glucopyranoside(7), kelampayoside A(8), descaffeoylpoliumoside(9), acteoside(10), alyssonoside(11), poliumoside(12), isacteoside(13), acetyl forsythoside B(14), and forsythoside B(15). Compounds 1 and 2 were novel, and the NMR data of compounds 3 and 4 were reported here for the first time. Furthermore, the hemostatic activities of the extract and abundant ingredients(compounds 12 and 15) of C. kwangtungensis were determined with Yunnan Baiyao as the positive control and normal saline as the negative control. The extract and compounds 12 and 15 significantly shortened the tail tip bleeding time in mice.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Hemostatics / China / Callicarpa / Glycosides Limits: Animals Country/Region as subject: Asia Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Hemostatics / China / Callicarpa / Glycosides Limits: Animals Country/Region as subject: Asia Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2023 Type: Article