Progress of research on the role of Atoh1 gene in the regeneration of mammalian auditory hair cells / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 614-617, 2023.
Article
in Zh
| WPRIM
| ID: wpr-981799
Responsible library:
WPRO
ABSTRACT
Atoh1 gene encodes a helix-loop-helix transcription factor which is involved in the generation and differentiation of mammalian auditory hair cells and supporting cells, and regulation of the proliferation of cochlear cells, therefore plays an important role in the pathogenesis and recovery of sensorineural deafness. This study reviews the progress of the Atoh1 gene in hair cell regeneration, with the aim of providing a reference for the study of hair cell regeneration gene therapy for sensorineural deafness.
Full text:
1
Index:
WPRIM
Main subject:
Regeneration
/
Transcription Factors
/
Cell Differentiation
/
Deafness
/
Basic Helix-Loop-Helix Transcription Factors
/
Hair Cells, Auditory
/
Hearing Loss, Sensorineural
/
Mammals
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2023
Type:
Article